Polyurethanes are produced by reacting with polyols. Other chemicals, such as catalysts, surfactants and flame retardants, may be included in the process. Atmospheric emissions of the diisocyanates MDI and TDI during isocyanate production and during most applications carried out in closed equipment with vent controls are usually low. 

Larger quantities of MDI and TDI are routinely transported in a variety of dedicated containers ranging from ships' tanks to drums. In the unlikely event of a spill to aquatic or soil environments, the MDI or TDI reacts to form inert polyureas. Of course, a spill must be addressed in accordance with applicable laws, and with appropriate reference to the manufacturer’s Safety Data Sheets (SDS). 

Facilities that manufacture, process or use MDI or TDI and exceed the threshold limits on atmospheric emissions set by the , are required by EPA to submit a Form A or Form R by July 1st of each reporting year to the EPA and the designated state agency. To provide general guidance during the reporting process, CPI offers a Regulatory Compliance Assistance Program (RCAP). While RCAP also offers individual assistance to RCAP users, each facility must independently determine its reporting obligations. For assistance or questions regarding MDI, PMDI, TDI or TRI reporting, contact CPI RCAP Software User Support.
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